Research Groups

Ageing Biology and Stem Cells

The general scope of studies in the Laboratory of Ageing Biology and Stem Cells is to further improve our understanding of mechanisms that specify normal hematopoietic stem cell functioning.

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  • Gerald de Haan Visit

    Scientific Co-Director, Group Leader of the Laboratory of Ageing Biology and Stem Cells

    Research fields

    Hematopoietic stem cells, aging, leukemia, genetics, epigenetics

    PhD Students
    Johannes Jung
    Seka Lazare
    Sara Russo Kraus
    Edyta Wojtowicz
    Postdoctoral Fellows
    Mirjam Belderbos
    Research Associates
    Leonid Bystrykh
    Bertien Dethmers
    Ellen Weersing
    Erik Zwart
  • The group is interested in the unique genetic and epigenetic program that distinguishes stem cells from non-stem cells. De Haan’s group uses state-of-the art genomic tools to search for common molecular events in stem cells at distinct phases in hematopoietic development and aging. The team studies how stem cells can be transplanted, and which mechanisms ensure their proper homing and subsequent engraftment to the bone marrow after transplantation. Stem cells are defined by their ability to self-renew and their ability to differentiate into all lineages within a tissue. The group is addressing how stem cell self-renewal alters with age, and how enhance stem cell renewal can be exploitated in stem cell expansion protocols in vivo and in vitro.

    • Maimets M, Bron R, de Haan G, van Os R, Coppes RP. (2015) Similar ex vivo expansion and post-irradiation regenerative potential of juvenile and aged salivary gland stem cells. Radiother Oncol.
    • Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y. (2015) Stem Cells and Aging: What's Next? Cell Stem Cell
    • Lalitha S Y Nanduri, Mirjam Baanstra, Hette Faber, Cecilia Rocchi, Erik Zwart, Gerald de Haan, Ronald van Os, Robert P Coppes. (2014) Purification and ex vivo expansion of fully functional salivary gland stem cells. Stem Cell Reports.
    • Klauke K, Broekhuis MJ, Weersing E, Dethmers-Ausema A, Ritsema M, González MV, Zwart E, Bystrykh LV, de Haan G. (2014) Tracing Dynamics and Clonal Heterogeneity of Cbx7-Induced Leukemic Stem Cells by Cellular Barcoding. Stem Cell Reports.
    • Prick J, de Haan G, Green AR, Kent DG. (2014) Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. Exp Hematol.
    • Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M. (2014) CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells. Mol Ther.
    • Korthuis PM, Berger G, Bakker B, Rozenveld-Geugien M, Jaques J, de Haan G, Schuringa JJ, Vellenga E, Schepers H. (2014) CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia. Leukemia.
    • Lazare SS, Wojtowicz EE, Bystrykh LV, de Haan G. (2014) microRNAs in hematopoiesis. Exp Cell Res.
    • Buschmann T, Zhang R, Brash DE, Bystrykh LV. (2014) Enhancing the detection of barcoded reads in high throughput DNA sequencing data by controlling the false discovery rate. BMC Bioinformatics.
    • Wojtowicz EE, Walasek MA, Broekhuis MJ, Weersing E, Ritsema M, Ausema A, Bystrykh LV, de Haan G. (2014) MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis. Exp Hematol.
    • Bystrykh LV, de Haan G, Verovskaya E. (2014) Barcoded vector libraries and retroviral or lentiviral barcoding of hematopoietic stem cells. Methods Mol Biol.
    • Ronald van Os and Gerald de Haan. (2014) Stem Cells, from basic research to therapy, Volume 2, chapter 1: Dynamics and aging of hematopoietic stem cells.ISBN 978-1-4822-1983-8
    • de Kruijf EJ, Alkemade GM, van Os R, Fibbe WE, van Pel M. (2014) Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency. Int J Hematol.
    • Dykstra B, Bystrykh LV. (2014) No monkeying around: clonal tracking of stem cells and progenitors in the macaque. Cell Stem Cell.
    • Verovskaya E, Broekhuis MJ, Zwart E, Weersing E, Ritsema M, Bosman LJ, van Poele T,de Haan G, Bystrykh LV. (2014) Asymmetry in skeletal distribution of mouse hematopoietic stem cell clones and their equilibration by mobilizing cytokines. The journal of experimental medicine.
    • E. Verovskaya and G. de Haan. (2013) Non-canonical Wnt comes of age in hematopoietic stem cells. Cell Stem Cell.
    • Duran AL, Potter P, Wells S, Kirkwood T, von Zglinicki T, McArdle A, Scudamore C, Meng QJ, de Haan G, Corcoran A, Bellantuono I. (2013) Shared Ageing Research Models (ShARM): a new facility to support ageing research. Biogerontology.
    • Nanduri LS, Lombaert IM, van der Zwaag M, Faber H, Brunsting JF, van Os RP, Coppes RP. (2013) Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiother Oncol.
    • Verovskaya E, Broekhuis MJ, Zwart E, Ritsema M, van Os R, de Haan G, Bystrykh LV. (2013) Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding. Blood.
    • Smit JK, Faber H, Niemantsverdriet M, Baanstra M, Bussink J, Hollema H, van Os RP, Plukker JT, Coppes RP. (2013) Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiother Oncol.
    • Geiger H, de Haan G, Florian MC. (2013) The ageing haematopoietic stem cell compartment. Nature reviews. Immunology.
    • Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. (2013) Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nature cell biology.
    • Glauche I et al. (2013) Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges. Blood cells, molecules & diseases.
    • Pringle S, Van Os R, Coppes RP. (2013) Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia. Stem Cells.
    • Radulović V, de Haan G, Klauke K. (2013) Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms. Leukemia.
    • Huls G, van Es J, Clevers H, de Haan G, van Os R. (2013) Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function. Leukemia.
    • Walasek MA, Bystrykh LV, Olthof S, de Haan G, van Os R. (2013) Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function. Experimental Hematology.
    • Bystrykh LV, Verovskaya E, Zwart E, Broekhuis M, de Haan G. (2012) Counting stem cells: methodological constraints. Nature Methods.
    • Gerrits A, Walasek MA, Olthof S, Weersing E, Ritsema M, Zwart E, van Os R, Bystrykh LV, de Haan G. (2012) Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells. Blood.
    • Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G. (2011) Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. The journal of experimental medicine.
    • Woolthuis CM, de Haan G, Huls G. (2011) Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?. Current opinion in immunology.
    • Klauke K, de Haan G. (2011) Polycomb group proteins in hematopoietic stem cell aging and malignancies. International journal of hematology.
    • Rizo A, Horton SJ, Olthof S, Dontje B, Ausema A, van Os R, van den Boom V, Vellenga E, de Haan G, Schuringa JJ. (2010) BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells. Blood.
    • Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, Broekhuis MJ, de Haan G, Bystrykh LV. (2010) Cellular barcoding tool for clonal analysis in the hematopoietic system. Blood.
    • Gerrits A, Li Y, Tesson BM, Bystrykh LV, Weersing E, Ausema A, Dontje B, Wang X, Breitling R, Jansen RC, de Haan G. (2009) Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genetics.
    • van Os R, de Haan G, Dykstra BJ. (2009) Hematopoietic stem cell quiescence: yet another role for p53. Cell stem cell.
    • Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de Haan G, Su AI, Jansen RC. (2008) Genetical genomics: spotlight on QTL hotspots. PLoS Genetics.
  • Aleksandra Rizo-Crcareva. Now Senior Director at Johnson & Johnson, New York, NY

    Alice Gerrits. Now Clinical Chemist, Isala Hospital Zwolle, the Netherlands

    Marta Walasek. Now Research Scientist Stem Cell Technologies, Vancouver, BC

    Karin Klauke. Now post-doc ERIBA, Groningen, the Netherlands

    Evgenia Verovskaya. Now post-doc at USCF, San Fransisco, CA

    Visnja Radulovic. Now post-doc Lund University, Sweden

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