Investigators
Position Professor Neurobiology of ion channels
Research fields biochemistry, biophysics, synthetic biology, and electrophysiology
  • Research Profile
  • Selected Publications
  • Armagan Kocer received her MSc (1995) and PhD (2000) in Biology from the Middle East Technical University, Ankara, Turkey. Part of her PhD work was carried out at the University of Groningen, under the supervision of Prof. George Robillard. In 2001, she joined the BiOMaDe Technology Foundation in Groningen, first as a research scientist and later as a senior scientist. At the end of 2007, she received two prestigious personal development grants from the Netherlands Organisation for Scientific Research (NWO-VIDI) and European Research Council (ERC Starting Grant). With these grants, she launched her research group at the University of Groningen.

    In 2014, she moved her research group to the University Medical Centre Groningen.Her research interests include ion channels in neurodegeneration, mechano-sensation at the molecular level, bio-hybrid sensors and triggered drug delivery systems. In 2012 and 2013, she received two ERC Proof of Concept grants to develop drug delivery and biosensor technologies.

     

    • C. E. Price, A. Koçer, S. Kol, J. P. van der Berg, A. J.M. Driessen (2011) In vitro synthesis and oligomerization of the mechanosensitive channel of large conductance, MscL, into a functional ion channel. FEBS Letters
    • A. Kocer, Lara Tauk,Philippe Dejardin (2012) Nanopore sensors: from hybrid to abiotic systems.  Biosensors and Bioelectronics
    • M. Urban, Al. Kleefen, N. Mukherjee, B. Windschiegl, P. Seelheim, M. vor der Brüggen, A. Koçer, and R. Tampé. (2014) Highly parallel transport recordings on a membrane-on-nanopore chip at single molecule resolution. Nano Letters
    • A. Koçer, M. Walko, E. Bulten, E. Halza, B. L. Feringa, W. Meijberg.(2006) Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH-Sensory Valve.  Angew. Chem. Int. Ed
    • A. Koçer.(2007) A Remote Controlled Valve in Liposomes for Triggered Liposomal Release. J Liposome Research
    • A Koçer (2009) Functional Liposomal Membranes for Triggered Release, Methods in Molecular Biology, vol. 605, 243-255. Liposomes (Volkman Weissig (ed) Humana Press
    • Jesus Pacheco-Torres, Nobina Mukherjee, Martin Walko, Pilar López-Larrubia, Paloma Ballesteros, Sebastian Cerdan and A. Kocer (2015) Image Guided Drug Release From pH-sensitive Ion Channel-functionalized Stealth Liposomes into an in vivo Glioblastoma Model.  Nanomedicine: Nanotechnology, Biology, and Medicine
    • D. Calle, D. Yilmaz, S. Cerdan, A. Kocer (2017) Drug delivery from engineered organisms and nanocarriers as monitored by multimodal imaging technologies.  AIMS Bioengineering
    • Koçer, M. Walko, W. Meijberg, B. L. Feringa. (2005) A Light-Actuated Nanovalve Derived from a Channel Protein. Science
    • Koçer, M. Walko, E. Bulten, E. Halza, B. L. Feringa, W. Meijberg.(2006) Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH-Sensory Valve. Angew. Chem. Int. Ed
    • Koçer, M. Walko, B. L. Feringa.(2007) Synthesis and Utilization of reversible and irreversible light-activatednanovalvesderived from the channel protein MscL. Nature Protocols
    • P. Birkner, B. Poolman, A. Koçer(2012) Hydrophobic gating of Mechanosensitive channel of large conductance evidenced by single-subunit resolution.   Proc Natl Acad Sci USA
    • D. Yilmaz, A. Konijnenberg, H. I. Ingólfsson, A. Dimitrova, S. J. Marrink, Z. Lid, C. Vénien-Bryand, F. Sobott and A. Koçer.(2013) Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry. Proc Natl Acad Sci USA
    • J. T. Mika, J. P. Birkner, D. Yilmaz, B. Poolman, A. Koçer (2013) On the role of individual subunits in MscL gating: All for one, one for all? FASEB J
    • Szymanski, D. Yilmaz, A. Kocer, B.L. Feringa.(2013) Bright ion channels and lipid bilayers. Accounts of Chemical Research
    • M.Barthmes, M. D.F. Jose, J. P. Birkner, A. Brüggemann, C. Wahl-Schott, A. Kocer (2014) Studying mechanosensitive ion channels with automated patch clamp. European Biophysics Journal
    • I. Ingólfsson, P. Thakur, K.F. Herold, E. A. Hobart, N. B. Ramsey, X. Periole, D. H. deJong,M. Zwama, D. Yilmaz, K. Hall, T. Maretzky, H. C. Hemmings, C. Blobel, S. J. Marrink, A.Kocer, J. T. Sack, O. S. Andersen(2014) Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chemical Biology
    • N.Mukherjee, M. D. Jose, J. P.Birkner, M. Walko, H. I. Ingólfsson, A. Dimitrova, C. Arnarez, S. J. Marrink, A. Koçer (2014) The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating. FASEB J
    • A. Konijnenberg, J. B. Gonzalez, L. Bannwarth, D. Yilmaz, A. Kocer, C. Venien-Bryan, N. Zitzmann and F. Sobott.(2015) Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment. Protein Science
    • D. Yilmaz, A. I. Dimitrova, M. Walko, A. Kocer. (2015) Study of light-induced MscL gating by EPR spectroscopy. European Biophysics Journal
    • A. Kocer.(2015) Mechanisms of mechanosensing - Mechanosensitive channels, function and re-engineering. Current Opinion In Chemical Biology
    • Dimitrova, Walko, M. Hashemi Shabestari, P. Kumar, M. Huber, and A. Kocer.(2016)In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions. Frontiers in Physiology
    • N. Melo, C. Arnarez, H. Sikkema, N. Kumar, M. Walko, H. J. C. Berendsen, A.Kocer, S. J. Marrink, H. I. Ingólfsson(2017) High-throughput simulations reveal membrane-mediated effects of alcohols on MscL gating. J. Am. Chem. Soc.
    • Halzǎ,T. Hedegaard Bro, B. Bilenberg,and A. Koçer * (2013) Well-Defined Microapertures for Ion Channel Biosensors. Anal. Chem.
    • Urban, Al. Kleefen, N. Mukherjee, B. Windschiegl, P. Seelheim, M. vor der Brüggen, A. Koçer, and R. Tampé (2014) Highly parallel transport recordings on a membrane-on-nanopore chip at single molecule resolution. Nano Letters
    • Mukherjee, M. D. Jose, J. P.Birkner, M. Walko, H. I. Ingólfsson, A. Dimitrova, C. Arnarez, S. J. Marrink, A. Koçer* (2014) The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating. FASEB J
    • Pacheco-Torres, N. Mukherjee, M. Walko, P.López-Larrubia, P. Ballesteros, S. Cerdan and A. Koçer* (2015) Image Guided Drug Release From pH-sensitive Ion Channel-functionalized Stealth Liposomes into an in vivo Glioblastoma Model. Nanomedicine:nanotechnology, biology, and medicine
    • Konijnenberg, D. Yilmaz, H. I. Ingólfsson, Anna Dimitrova, Siewert J. Marrink, Z. Lid, C. Vénien-Bryand, F. Sobott and Koçer*(2014) Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry. Proc Natl Acad Sci USA
    • Szymanski, D. Yilmaz, A. Koçer*, B.L. Feringa* (2013) Bright ion channels and lipid bilayers. Accounts of Chemical Research
    • P. Birkner, B. Poolman, A. Koçer* (2012) Hydrophobic gating of Mechanosensitive channel of large conductance evidenced by single-subunit resolution.  Proc Natl Acad Sci USA
    • Koçer*, M. Walko, B. L. Feringa*. (2007) Synthesis and Utilization of reversible and irreversible light-activated nanovalves derived from the channel protein MscL. Nature Protocols
    • A. Koçer, M. Walko, E. Bulten, E. Halza, B. L. Feringa, W. Meijberg. (2006) Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH-Sensory Valve. Angew. Chem. Int. Ed.
    • Koçer, M. Walko, W. Meijberg, B. L. Feringa. (2005) A Light-Actuated Nanovalve Derived from a Channel Protein. Science 
Share this:
Your browser is out-of-date!

Update your browser to view this website correctly. Update my browser now

×