Principal Investigator
Position Head of the Section Molecular Neurobiology Professor of Molecular Neuroimmunology
Research fields Neuroscience, epigenetics, innate immunity
  • Research Profile
  • Selected Publications
  • Bart Eggen received his MSc (1989) and PhD (1995) from the University of Utrecht. As a graduate student, he worked on the regulation of B-50/GAP-43 gene expression in the Department of Physiological Chemistry and the Rudolf Magnus Institute, Utrecht, with Prof. Loes Schrama and Prof. Willem Hendrik Gispen.

    He obtained a Human Frontiers Science Program fellowship to work with Prof. Gail Mandel at the State University of New York and later with Prof. Ali Hemmati Brivanlou at the Rockefeller University in New York on the characterization of the transcriptional repressor protein REST/NRSF that controls neuron-specific gene expression. In 2000, he joined the Department of Developmental Genetics at the University of Groningen to work on the epigenetic regulation of embryonic stem cell pluripotency.

    In 2010, he moved to the Department of Neuroscience at the UMCG. There his main research focus is on the (epi)genetic regulation of microglia identity and function in the context of the normal brain, during aging and under neuroinflammatory or neurodegenerative conditions such as multiple sclerosis and Alzheimer’s disease.

     

     

    • Wes PD, Holtman IR, Boddeke HWGM, Möller T, Eggen BJ (2016)Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia
    • Holtman IR, Noback M, Bijlsma M, Duong KN, van der Geest MA, Ketelaars PT, Vainchtein ID, Eggen BJ*, Boddeke HWGM* (2015) Glia Open Access Database (GOAD): A Comprehensive Gene Expression Encyclopedia of Glia cells in Health and Disease. Glia
    • Schaafsma W, Zhang X, van Zomeren KC, Jacobs S, Georgieva PB, Wolf SA, Kettenmann H, Janova H, Saiepour N, Hanisch U-K, Meerlo P, van den Elsen PJ, Brouwer N, Boddeke HWGM, Eggen BJ (2015) Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing. Brain Behavior and Immunity
    • Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes, PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke HWGM, Eggen BJ(2015)Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropath Comm
    • Raj D, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer M, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JHJ, Eggen BJ, Boddeke HWGM (2014) Priming of Microglia in a DNA Repair Deficient Model of Accelerated Aging. Neurobiol of Aging
    • Vainchtein ID, Vinet J, Brouwer N, Brendecke S, Biagini G, Biber KP, Boddeke HWGM, Eggen BJ (2014) In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed. Glia
    • Kooistra SM, van den Boom V, Thummer RP, Johannes F, Wardenaar R, Tesson BM, Veenhoff LM, Fusetti F, O’Neill LP, Turner BM, de Haan G, Eggen BJ (2010) UTF1 regulates ES cell chromatin organization and gene expression. Stem Cells
    • Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ (2007) Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation. J Biol Chem
    • van den Boom V, Kooistra SM, Boesjes M, Geverts B, Houtsmuller AB, Monzen K, Komuro I, Essers J, Drenth-Diephuis LJ, Eggen BJ (2007) UTF1 is a chromatin-associated protein involved in ES cell differentiation. J Cell Biol
    • Benus GF, Wierenga AT, de Gorter DJ, Schuringa JJ, van Bennekum AM, Drenth-Diephuis LJ, Vellenga E, Eggen BJ (2005)Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3. Mol Biol Cell
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