Title: Microglia phenotypes in neurodegenerative diseases and aging
Project: My project is focused on the role of microglia in neurodegenerative diseases such as Alzheimer’s Disease. Microglia exert many functions in the brain, resulting in a whole spectrum of microglial phenotypes. Several functions of microglia are associated with the immune system, where microglia function as macrophages and secrete cytokines. To study their role in Alzheimer’s Disease I work with human post-mortem brain tissue obtained from the Dutch Brainbank, from which we isolate microglia. In order to further elucidate microglia phenotypes in this disease paradigm, I focus on plaque-associated microglia and transcriptomics.