Principal Investigator
Position Vice Dean Research of the UMCG,
Research fields microglia, epigenetics, aging, Multiple Sclerosis
  • Research Profile
  • Selected Publications
  • Erik Boddeke is Professor of Medical Physiology and Neurophysiology at the Department of Neuroscience of the University of Groningen/University Medical Centre Groningen (UMCG). He finished his PhD thesis at the Department of Pharmacology of the University of Amsterdam. From 1988 to 1996, he was the laboratory head and group leader of Neuroimmunology at Sandoz, Basle, Switzerland. From 1996 to 1998, he was Vice Head of the Department of Neurogenetics at Novartis Research in Basle.

    In 1998, he became Professor of Physiology at the Department of Medical Physiology at the UMCG, and in 2015 he became Vice Dean of Research of the UMCG.

     

    • Biber K, Möller T, Boddeke E, Prinz M. (2016)Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat Rev Drug Discov.
    • Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW (2015) Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging Cell.
    • Muñoz-Llancao P, Henríquez DR, Wilson C, Bodaleo F, Boddeke EW, Lezoualc'h F, Schmidt M, González-Billault C.(2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Neurosci
    • Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ. (2015) Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathol Commun.
    • Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. (2015) Neuroinflammation in Alzheimer's disease. Lancet Neurol.
    • Holtman IR, Noback M, Bijlsma M, Duong KN, van der Geest MA, Ketelaars PT, Brouwer N, Vainchtein ID, Eggen BJ, Boddeke HW. (2015) Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Glia
    • Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW. (2014) Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiol Aging
    • Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. (2013) Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell
    • Duarri A, Jezierska J, Fokkens M, Meijer M, Schelhaas HJ, den Dunnen WF, van Dijk F, Verschuuren-Bemelmans C, Hageman G, van de Vlies P, Küsters B, van de Warrenburg BP, Kremer B, Wijmenga C, Sinke RJ, Swertz MA, Kampinga HH, Boddeke E, Verbeek DS. (2012) Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19. Ann Neurol
    • Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. (2011) Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development Embo J.
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