Principal Investigator
Position Group leader of Motor control and Fatigue
Research fields Force modulation, central and peripheral fatigue, spinal cord injury, multiple sclerosis
  • Research Profile
  • Selected Publications
  • Inge Zijdewind received her MSc from the Free University Amsterdam (Human Movement Sciences), in 1989. In 1993, she obtained her PhD from the University of Amsterdam supervised by Prof. Daniel Kernell. That same year she started as a postdoc in the Department of Medical Physiology of the University of Groningen.

    Throughout her career, she has studied fatigue and fatigability in healthy control subjects and in various patients groups. Fatigue refers to an increased perception whereas fatigability refers to a decline in performance. Although mechanisms underlying increased perception of fatigue are still unknown we examine the hypothesis that fatigue is attributable to interactions between the central nervous system en the immune system which exacerbate both the perception of fatigue and the fatigability. Fatigue and fatigability is in detail studied in patients with multiple sclerosis, mild traumatic brain injury, spinal cord injury and healthy aging subject with the usage of electromyography recordings, force measurements, peripheral nerve stimulation, functional magnetic resonance imaging and transcranial magnetic stimulation.

     

     

    • Wolkorte R, Heersema DJ, Zijdewind I. (2015) Muscle Fatigability During a Sustained Index Finger Abduction and Depression Scores Are Associated With Perceived Fatigue in Patients With Relapsing-Remitting Multiple Sclerosis. Neurorehabilitation Neural Repair.
    • Prak RF, Doestzada M, Thomas CK, Tepper M, Zijdewind I (2015). Reduced voluntary drive during sustained but not during brief maximal voluntary contractions in the first dorsal interosseous weakened by spinal cord injury. J Appl Physiol
    • Wolkorte R, Heersema DJ, Zijdewind I (2015) Reduced Dual-Task Performance in MS Patients Is Further Decreased by Muscle Fatigue. Neurorehabil Neural Repair.
    • Thomas CK, Bakels R, Klein CS, Zijdewind I (2014). Human spinal cord injury: motor unit properties and behavior. Acta Physiol.
    • Wolkorte R, Kamphuis J, Zijdewind I. (2014). Increased reaction times and reduced response preparation already starts at middle age. Front Aging Neurosci.
    • Heetkamp J, Hortobágyi T, Zijdewind I. (2014). Increased bilateral interactions in middle-aged subjects. Front Aging Neurosci.
    • Steens A, de Vries A, Hemmen J, Heersema T, Heerings M, Maurits N, Zijdewind I (2012). Fatigue perceived by Multiple Sclerosis patients is associated with muscle fatigue. Neurorehab Neural Repair
    • Zijdewind I, Thomas CK (2012). Firing patterns of spontaneously active motor units in spinal cord-injured subjects. J Physiol
    • Roosink M, Zijdewind I (2010). Corticospinal excitability during observation and imagery of simple and complex hand tasks: implications for motor rehabilitation. PLOS One
    • Post M, Bakels, R, Zijdewind I (2009). Inadvertent contralateral activity during a sustained unilateral contraction reflects the direction of target movement. J Neuroscience
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