Title: Epigenetic regulation and functional consequences of microglia phenotypic diversity
Project: The functionality of the central nervous system (CNS) can be strongly influenced by peripheral challenges such as infection and trauma. Peripheral inflammation or inflammation is a major medical problem in various CNS disorders. Microglia are the tissue macrophages of the CNS, specifically tailored to their functions in the CNS including maintenance of homeostasis. Microglia are increasingly implicated in a range of neuropathological and neurodegenerative disorders such as Alzheimer’s disease, multiple sclerosis, and aging. Microglia are versatile cells that adopt a range of phenotypes that depend on the type, amount, duration and frequency of the stimulus they are exposed to. In my project, I’m investigating microglia heterogeneity in response to peripheral inflammation in transcriptomic and epigenetic level.
Funding: China Scholarship Council