The accumulation of aggregation-prone disease proteins in aggregates in the brain is the major pathological hallmark of several age-related neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. To understand disease mechanisms, the group led by Ellen Nollen aims to uncover the cellular pathways that regulate disease-protein toxicity, aggregation, and spreading.
Group Leader of the Laboratory of Molecular Neurobiology of Ageing
Protein aggregation, neurodegeneration, ageing, c. elegans
To identify cellular pathways and better understand the molecular function of regulators of age-related protein aggregation, toxicity, and spreading, the group is combining the power of C. elegans genetics with the development of cell-biological and biochemical tools to monitor aggregation, toxicity, and cell-to-cell transmission of aggregation-prone proteins in living worms. Nollen’s team aims to translate findings in worms to mice and patient-derived cells. Their studies will provide new mechanistic insights into how human cells cope with protein damage in health, aging and disease.